BCO1 and obesity due to melanocortin 4 receptor deficiency: We previously reported that BCMO expression is altered in several peripheral tissues in pathological conditions including nephrosis, obesity with dyslipidemia, type 1 diabetes, type 2 diabetes, and non-alcoholic fatty liver disease (NAFLD); moreover, it can also be altered by biological substances such as dehydroepiandrosterone [27,28,29,30,31,32].