Induced AMP expression has been previously reported in ARCI patients with TGM1 mutations, as well as in TGm1‐deficient mice.24 Our study revealed a number of highly expressed transcripts encoding proteins with antimicrobial activity, viz. S100‐A7, S100‐A7A, the S100‐A8/S100‐A9 complex (calprotectin), SKALP/ELAFIN and beta defensin‐4A and 4B. Here, PI3 is linked to autosomal recessive congenital ichthyosis.