Furthermore, we previously analysed several retinoid‐regulated genes in healthy volunteers exposed to topical atRA38 and lamellar ichthyosis patients treated systemically with the retinoic acid‐metabolism blocking agent, liarozole,39 and among all genes found to be upregulated in these reports, only CRABP2 was upregulated in the ARCI patients of this study. Here, CRABP2 is linked to autosomal recessive congenital ichthyosis.