We performed a microarray analysis to investigate the global mRNA expression profile in skin biopsies from five male patients (P1‐5) with ARCI in different severity and various types of inactivating TGM1 mutations (Table 1) and four healthy controls (aged 39‐68; C1, C2, C4 male and C3 female). This evidence concerns the gene TGM1 and autosomal recessive congenital ichthyosis.