VEGFA and diabetic retinopathy: This study corroborated several other reports that has shown rapid regression of retinal neovascularization or significant improvement in diabetic retinopathy severity with anti-VEGF therapy.5,10,14,21, , –24 The new vessels regressed completely after the three loading injections of aflibercept and more than half of eyes (10 of 18) remained completely regressed at 52 weeks despite an average of 1.4 supplemental aflibercept injections over the next 40 weeks, suggesting an immediate but prolonged effect of aflibercept on regression of new vessels.