TNFRSF8 and cancer: As presented in Fig. 3A, LR004‐VC‐MMAE inhibited the viability of A431 in a concentration‐dependent manner, with an IC50 value of 0.019 ± 0.006 nm, and showed a high tumor growth inhibition ratio (91.17%) at a dose of 1 μg·mL−1 (6 nm), whereas the Karpass 299 cells (CD30‐overexpressing cancer cells) were not sensitive to LR004‐VC‐MMAE up to the maximum concentration of 1 μg·mL−1 but had superior activity to anti‐CD30‐VC‐MMAE, with an IC50 of 0.088 ± 0.002 nm.