These findings will begin to expand the complexity of the genetic underpinning of this group of diseases especially since peroxisome proliferator activated receptor gamma (PPARG) is one of the major hubs in the pathway, and also directly influenced by Prdm1, and is associated with lichen planopilaris, one of the human primary cicatricial alopecias [5, 33]. The gene discussed is PRDM1; the disease is cicatricial alopecia.