Since aberrant activation and overexpression of the proinflammatory transcription factor, NF-κB plays a key role in regulating wide variety of cellular processes including cell differentiation, apoptosis, transformation and signal transduction pathways, specifically during progression and metastasis of several cancers including oral cancer, it is important to unpave the role of NF-κB proteins. This evidence concerns the gene NFKB1 and cancer.