We have therefore investigated the role of NF-κB and its family proteins along with selected miRNAs in SP (sphere forming stem cells), Non SP and parental OSCC cells derivedfrom cell lines as well as fresh tumor tissues to understand the role of NF-κB and miRNAs in presence or absence of HPV infection for tumorogenic progression and prognosis of oral cancer. The gene discussed is NFKB1; the disease is neoplasm.