Bellei et al. [2012] noted that β‐catenin has a critical role in prenatal melanocyte biology; they recently demonstrated a physical interaction between CREB and β‐catenin following PKA/cAMP pathway activation in normal human melanocytes and B16‐F0 mouse melanoma cells, which led to the functional cooperation of β‐catenin and CREB on the MITF promoter. Here, CREB1 is linked to melanoma.