On the other hand, there was no increased incidence of serious adverse reactions in the CAI group in the study of Faisy et al., as defined by events that required intensive care procedures and/or surgery, and events that prolonged hospitalization or resulted in persistent or major disability/incapacity, and in Rialp Cervera et al. as defined by serum creatinine > 2.5 g/dL, bilirubin > 3.5 mg/dL, prothrombin activity < 40%, leukocyte count < 4 × 109/L, platelets < 150 × 109/L, appearance of seizures, or severe allergic reaction [6, 8]. This evidence concerns the gene F2 and allergic disease.