The results were similar (hazard ratio 1.09, 95% CI 0.86‐1.39) when all covariates with P<0.2 in univariate cox regression model (including age, estimated glomerular filtration rate, left atrial diameter, moderate‐to‐severe mitral regurgitation, history of congestive heart failure, hypertension, diabetes mellitus, thromboembolism, vascular disease, previous bleeding, use of angiotensin‐converting enzyme inhibitor and/or angiotensin II receptor blocker, and completion of high school) were adjusted. This evidence concerns the gene ACE and Mitral regurgitation.