The orphan nuclear receptor small heterodimer partner (SHP) has been identified as a target for 3‐Cl‐AHPC to exert its anti‐cancer effect.49, 50 However, whether 3‐Cl‐AHPC binding to SHP is responsible for its induction of matriptase/HAI‐1 complex remains to be clarified. The gene discussed is SPINT1; the disease is cancer.