HGF and cancer: Matriptase is involved in the maturation of pro‐HGF via cleavage.48 Matriptase fails to promote tumour progression in epidermal‐deficient c‐Met mice, which indicates that pro‐HGF‐cleaving activation is an essential step by which matriptase exerts cancer promotion.2, 3, 4, 48 3‐Cl‐AHPC inhibits pro‐HGF‐induced signal transduction and cell scattering (Figures 4 and 5).