The insufficient HAI‐1 leads to the higher matriptase/HAI‐1 ratio and aberrant matriptase activity.3, 4 Engineered expression of HAI‐1 dramatically inhibits the invasion and migration of cervical, endometrial and uterine cancer cells in vitro.1, 2, 3, 4 However, the approach to increase HAI‐1 expression in vivo or in patient is not easy to achieve. This evidence concerns the gene SPINT1 and uterine cancer.