The shed matriptase contains the catalytic ectodomain and in tumour microenvironment may more readily activate oncogenic substrates and change the ECM contributing to tumour progression.7, 46, 47 3‐Cl‐AHPC also induces matriptase shedding (Figure 2B), but it is not certain whether 3‐Cl‐AHPC‐induced matriptase/HAI‐1 complex formation and shedding are correlative or not. This evidence concerns the gene SPINT1 and neoplasm.