The moderate growth suppressive effects of FAK inhibitor were consistent with the results obtained in human HCC cells subjected to FAK silencing using specific shRNA.40 Importantly, PND‐1186 effectively inhibited Dasatinib induced p‐FAK expression, and it synergized with Dasatinib to inhibit HCC cell growth in vitro by decreasing proliferation and inducing apoptosis. Here, PTK2 is linked to hepatocellular carcinoma.