Previously, we established a c‐Myc driven murine HCC model by hydrodynamically injecting c‐Myc into the mouse liver (c‐Myc mice).13, 27 These mice were found to develop HCC lesions starting ~3 weeks post hydrodynamic injection, and mice had to be euthanized due to high liver tumor burden by 7 weeks post injection.13, 27. Here, MYC is linked to hepatocellular carcinoma.