Using hydrodynamic transfection, we previously established a murine HCC model for c‐Myc induced HCC.13, 27 This preclinical model has been useful to dissecting the genetic alterations, signaling pathways, and metabolic cascades required for Myc‐induced hepatocarcinogenesis, as well as for testing drugs that may be useful for treating c‐Myc positive HCC.27, 31, 32, 33, 34, 35 In the present investigation, we tested the therapeutic potential of Dasatinib for c‐Myc induced HCC using this preclinical model. Here, MYC is linked to hepatocellular carcinoma.