To be noted, previous studies have reported unconventional risk factors such as log odds of positive lymph nodes (LODDS) or MACC1 levels could improve the prognostic power of the stratified risk factors in CRC patients.7, 8 Herein, we evaluate the impact of plasma MACC1 levels on the prognostic stratification of clinical variables (Table 1). The gene discussed is MACC1; the disease is colorectal carcinoma.