We have previously demonstrated that ATX levels were associated with IL-6, sCD14, sCD163, Mac2BP, and Lysophosphatidic acid (LPA) levels in HCV-infection, and that ATX, LPA, and sCD14 levels normalized, while CD163 and Mac2BP levels partially normalized within 6 months of starting IFN-free DAA HCV therapy [22]. The gene discussed is ENPP2; the disease is infection.