In response to calcium stimulation, CaMKII (Calcium/calmodulin-dependent protein kinase II) mediates S90 phosphorylation, which facilitates K63-ubiquitination-dependent autophagic degradation of Id1/2 (inhibitor of differentiation-1/2) promoting neuroblastoma differentiation (Li et al., 2017). Here, ID1 is linked to neuroblastoma.