The presence in the HPV(+) as well as HPV(−) exosomes of FasL, LAP-TGFβ and potentially other tumor-derived immunosuppressive proteins appears to counterbalance co-stimulatory signaling, leading to surface receptor-mediated suppression of T-cell functions by tumor-derived exosomes regardless of their HPV status. This evidence concerns the gene FASLG and neoplasm.