The somatic mutations gene list (GATA3, ESR1, TBX3, RUNX1, NCOR1, KMT2C, SPEN, ARID1A, NOTCH2, MAP2K4, RB1, MTOR, MED12, and LRP1B) was selected from somatic mutations in the cancer (COSMIC) database. The gene discussed is SPEN; the disease is cancer.