Since the EVI2B (Ectopic viral integration site 2B protein homolog) gene lies within an intron of the NF1 (Neurofibromatosis type 1) gene and is transcribed in the opposite direction to the NF1 gene (28), we compared NF1 and EVI2B RNA expression levels in relation to those of the estrogen receptor gene ESR1 in the genome-wide RNA transcript profile from TCGA (breast invasive carcinoma gene expression) using the RNAseq data set (TCGA_BRCA_exp_HiSeqV2-2017-09-08; in 1,218 tumor tissue samples). The gene discussed is EVI2B; the disease is neurofibromatosis.