For example, USP7 changes the localization of monoubiquitinated FOXO4 and PTEN through removal of the single ubiquitin molecule20–22 and can regulate the stability of p53, MDM2, N-MYC, TRIP12, FOXP3, ASXL1, UHRF1, PHF8, and DNMT1.23–30 Many of the preceding factors are critical in cancer development, epigenetic control, cell signaling, DNA damage repair, and immune responses. The gene discussed is USP7; the disease is cancer.