Bioinformatics analysis revealed that the USP7 mRNA expression was higher in NOTCH1 mutant than in the NOTCH1 wild-type T-ALL patients, indicating that mutation of NOTCH1 may upregulate the mRNA level of USP7. A positive feedback loop may exist between USP7 and NOTCH1: USP7 stabilizes and deubiquitinates NOTCH1, which in turn facilitates transactivation of USP7. Further studies are needed to verify this speculation. Here, NOTCH1 is linked to acute lymphoblastic leukemia.