NOTCH1 and acute lymphoblastic leukemia: Treatment of T-ALL cell lines (JURKAT, MOLT-4, CUTLL1, CCRF-CEM, and KOPT-K1) with P22077 led to a reduction in the ICN1 protein level in a dose-dependent manner (Fig. 1d) without changing the NOTCH1 mRNA level (Supplementary Fig. S1A and S1B).