Interestingly, USP7 inhibition caused degradation of ICN1 in T-ALL cell lines regardless of the status of NOTCH1 (JURKAT and CCRF-CEM cells have FBW7 mutations; MOLT-4 and KOPT-K1 cells have PEST domain mutations;45 CUTLL1 cells harbor a chromosomal translocation at (7;9)(q34;q34)46). Here, USP7 is linked to acute lymphoblastic leukemia.