Kang et al. discovered that melbine (DMBG) could mediate ATF2/CREB-PGC-1α pathway, induce proteomic change of metabolisms and mitochondria pathways in the substantia nigra, increase mitochondrial protein in the substantia nigra and the corpus striatum, protect dopaminergic neuron in the substantia nigra and the corpus striatum, and improve dyskinesia of PD [24]. This evidence concerns the gene CREB1 and Parkinson disease.