As the data in Figure 4(c) show, the tumor burden for the Tg(TXN)+/0 mice is significantly higher (24.4% higher) than that of WT mice (p = 0.043), suggesting that the overall tumor incidence is higher in the Tg(TXN)+/0 mice than WT mice, which is similar to our previous study that showed the incidence of fatal tumors was higher in the Tg(act-TXN)+/0 compared to WT mice [20]. This evidence concerns the gene TXN and neoplasm.