The cross-sectional pathological analyses of 38 Tg(TXN)+/0 and 48 WT mice (22–25 months) showed that the major disease in these mice was neoplastic disease, especially lymphoma (Figure 4(a,b)), which is consistent with the end-of-life pathology data from C57BL/6 mice and Tg(act-TXN)+/0 mice [20,28,29]. The gene discussed is TXN; the disease is neoplasm.