Bach1 also promotes temozolomide (TMZ) resistance in patients with glioblastoma by antagonizing the p53-mediated suppression of O6-methylguanine DNA methyltransferase (MGMT); once activated, MGMT counteracts the antitumor effect of TMZ by reversing the TMZ-induced methylation of guanine residues [56]. The gene discussed is MGMT; the disease is glioblastoma.