BACH1 and malignant colon neoplasm: Bach1 depletion had no effect on the growth of breast cancer cells in culture or on primary tumor growth in mice [48]; however, the expression of Bach1 and its target genes has been linked to a higher risk of breast cancer recurrence in patients [49], as well as increases in cell invasion and migration of prostate and colon cancer cells [50–52], while lower Bach1 levels have been associated with declines in breast tumor metastasis [48].