CHD8 and neoplasm: In both colorectal cancer and melanoma, the B-Raf protooncogene variant BRAF (V600E) upregulates v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog G (MAFG), which heterodimerizes with Bach1 and recruits both chromodomain helicase DNA-binding protein 8 (CHD8, a chromatin remodeling factor) and the DNA methyltransferase DNMT3B, leading to the hypermethylation and transcriptional silencing of tumor-suppressor genes [54, 55] (Figure 4).