In view of evidence that the induction of a dedifferentiated state caused by c-Myc overexpression contributes to pancreatic carcinogenesis [18] and our findings, this may help explain the downregulation of EI24 in PDAC compared with normal pancreatic acinus/islands and lower expression level in poorly differentiated cancer cells compared with well- and moderately differentiated cancer cells. The gene discussed is EI24; the disease is cancer.