In many tumors, such as breast cancer, head, and neck squamous cell carcinoma and NSCLC, TOP2A expression is significantly higher in middle and low differentiated tumors than in high differentiated ones (Nakopoulou et al., 2000; Stathopoulos et al., 2000; Sun and Wu, 2004). The gene discussed is TOP2A; the disease is non-small cell lung carcinoma.