Ubiquitin-conjugating enzyme E2C (UBE2C), which encodes a member of the E2 ubiquitin-conjugating enzyme family, had been reported to serve momentous roles in various malignancies, including breast cancer, colorectal cancer, and hepatocellular carcinoma (Ieta et al., 2007; Loussouarn et al., 2009; Chen et al., 2010; Bavi et al., 2011). The gene discussed is UBE2S; the disease is breast cancer.