It was found that high expression of TOP2A [HR 1.65 (1.45–1.87), P = 1.3e–14], CCNB1 [HR 1.63 (1.38–1.92), P = 7.3e–09], CCNA2 [HR 1.57 (1.39–1.79), P = 2.2e–12)], UBE2C [HR 1.77 (1.55–2.01), P < 1e–16], and KIF20A [HR 1.66 (1.46–1.89), P = 5.1e–15] was associated with worse OS for NSCLC patients. This evidence concerns the gene TOP2A and non-small cell lung carcinoma.