iNKT cells promote virus control also by promoting differentiation into functional APC of lung-infiltrating immature myeloid derived cells, through CD40 engagement and CD1d cognate recognition (17), or by reducing pathogenic inflammatory monocytes (Ly6ChighLy6G−) via direct lysis (112), which correlates with better influenza outcome in iNKT cell-sufficient compared to insufficient mice. This evidence concerns the gene CD1D and influenza.