Transcriptomic and proteomic profiling revealed that EVs derived from metastatic HCC cells carry a larger number of pro-tumorigenic RNAs and proteins, such as MET proto-oncogene, S100 family members (S100A4, S100A10, and S100A11) and the caveolins (CAV1 and CAV2). This evidence concerns the gene MET and hepatocellular carcinoma.