in vivo modelsThe data on the in vivo role are controversial. Fayad et al. provided evidence suggesting a pro-inflammatory role for adiponectin in DSS- as well as TNBS-induced colitis. Conversely, Nishihara et al. found the opposite. In addition, work by Sideri et al. demonstrated that silencing of AdipoR1 was followed by deterioration of TNBS-induced colitis. These obvious discrepancies might be explained by differences in knockout mice. The gene discussed is ADIPOR1; the disease is colitis.