The study by Yamamoto et al. analyzed the adiponectin expression in the creeping fat of Crohn's disease patients, that revealed an upregulation of adiponectin expression in creeping fat of Crohn's disease patients when compared to non-creeping fat of Crohn's disease patients as well as fat from ulcerative colitis patients or controls (11). This evidence concerns the gene ADIPOQ and ulcerative colitis.