RNASEL and infection: RNase L inhibition by EMCV-induced RLI is, however, partial as RNase L antiviral activity against EMCV was demonstrated in vitro using dominant negative RNase L and OAS1 overexpression (Chebath et al., 1987; Zhou et al., 1998) and in vivo, in RNase L-deficient mice, which presented increased EMCV infection and mortality compared to wild-type mice (Zhou et al., 1997).