PINK1 and Parkinson disease: Complex I deficiency in PD brain within the substantia nigra Oxidative damage from enhanced ROS production damage dopaminergic neuronsGenetic overlap between PD and mitochondrial dysregulation:Under-expression of genes regulating pyruvate metabolism and ETC in the dopaminergic neurons of SNpc of PD patientsMutations in PINK1 reduce energy production death of dopaminergic neuronsImpaired degradation of MIRO defective clearance of damaged mitochondria