RETN and obesity due to melanocortin 4 receptor deficiency: To corroborate our newly proposed Type II MHO model, we show that the proinflammatory adipokine, resistin, is significantly increased in adipose tissue of our MHO mice following high-fat diet (HFD) feeding, revealing a miR-155-suppressed adipose-tissue generated inflammatory state, characteristic of MHO transition to classical obesity (Jung et al., 2017).