TF and obesity due to melanocortin 4 receptor deficiency: NFκB is a pleiotropic TF that regulates cell death, proliferation, the immune response, and plays a role in a host of diseases (Hayden and Ghosh, 2012), including promoting atherosclerosis (Pamukcu et al., 2011), being associated with obesity, T2DM (Baker et al., 2011) and, as some evidence suggests, being associated with NAFLD (Zeng et al., 2014).