In glioma cells on the other hand, overexpression of anti-tumorigenic gene, melanoma antigen family D1 (DLXIN-1), resulted in less proliferation due to less matrix metalloproteinases (MMP)2 and 9 activity and through direct interaction with P311, DLXIN-1 blocks P311’s invasive function. This evidence concerns the gene NREP and central nervous system cancer.