Synergistic impairment of multiple neuron types: excitatory pyramidal neurons, PV interneurons and SST interneurons, are likely responsible for the neurological phenotypes of social deficits, repetitive behaviors, cognitive impairments and chronic seizures seen in APC cKO mice (Mohn et al., 2014; Pirone et al., 2017). The gene discussed is SST; the disease is Cognitive impairment.