MT-ND5 and myeloid sarcoma: The first meta-analysis studying more than 2500 MS samples and the same number of controls found that the variant m.13708G > A: MT-ND5, defining the haplogroup J, was significantly associated with an increased risk to MS [OR = 1.71, P = 0.0002, CI 95% (1.29–2.27)] (Yu et al., 2008).