When comparing the top versus the bottom tertile of baseline osteoprotegerin concentration, the risk ratio was 1.24 (95% CI, 0.94–1.64; 8 studies; 1592 events; P=0.128) for CHD and 1.21 (95% CI, 0.97–1.50; 4 studies; 260 events; P=0.090) for stroke (Figure 5). This evidence concerns the gene TNFRSF11B and stroke disorder.