Testis cancer, in particular seminoma and extragonadal germ cell cancer occur with a slightly greater risk in HIV-infected patients, without relation to CD4 count (two large series with 34 and 35 patients each one, reported the median CD4 count at cancer diagnosis was 325 and 315 cells/μL, respectively) [27]. The gene discussed is CD4; the disease is extragonadal germ cell cancer.