MNX1 and pancreatic insulinoma: However, the expression of MNX1 has been reported to be upregulated in several tumors, including prostate cancer, hepatocellular carcinoma (HCC), acute myeloid leukemia (AML), and neuroblastoma.3, 9, 10, 11 Furthermore, it has been demonstrated to be oncogenic in prostate cancer and insulinoma.12, 13