BCL2 and neoplasm: In response to oxidative stress, PKM2 promotes cell survival by translocating into the mitochondria, phosphorylating the apoptosis regulator Bcl2 at Thr69 to stabilize Bcl2, which blocks its association with Cul3-based E3 ligase to prevent the degradation of Bcl2 and promotes the resistance of tumor cells against apoptosis [19].