Further, as PKM2 can also phosphorylate the synaptosome-associated protein 23 (SNAP23) at Ser95, resulting in the formation of the soluble N-ethylmaleimide sensitive factor attachment protein receptors (SNARE) complex, this demonstrates that PKM2 has contribution in the remodeling of the tumor microenvironments by promoting tumor cell exosome secretions, which are necessary for the docking of tumor cells to plasma membranes [20]. Here, PKM is linked to neoplasm.