In response to stresses such as hypoxia the amount of nutrients becomes limited, conditions commonly observed in tumor microenvironments, and cytosolic ACSS2 is translocated to the nucleus, where it forms a complex with transcription factor EB (TFEB), locally producing acetyl-CoA for histone H3 acetylation in the promoter regions of TFEB-regulated autophagosomal and lysosomal genes. This evidence concerns the gene TFEB and neoplasm.