However, other data suggest that immune hypo-responsiveness in diabetes mellitus is reversed by insulin therapy, and associated with alveolar neutrophil infiltration and increased alveolar concentration of pro-inflammatory cytokines in lipopolysaccharide (LPS)-induced lung injury [33], suggesting that insulin may restore immune function and therefore could reverse some of the protective effects of diabetes mellitus in relation to ARDS. The gene discussed is INS; the disease is diabetes mellitus.