In the DM RP-ILD group, serum IFN-γ was elevated even in anti-MDA5 antibody-negative cases, whereas in the DM without RP-ILD group, serum IFN-γ was not elevated even in the majority of anti-MDA5 antibody-positive cases (Additional file 1: Table S1 and Additional file 2: Table S2). The gene discussed is IFIH1; the disease is interstitial lung disease.