Aggregation of many RBPs, such as TIA-1 [18], FUS, TDP43, hnRNPA1 and hnRNPA2 in Amyotrophic lateral sclerosis/frontotemporal dementia (ALS/FTD) proteinopathies are mediated by prion-related domain (PRD) [29, 39]. Here, TARDBP is linked to frontotemporal dementia and/or amyotrophic lateral sclerosis.