The Early Use of Polymyxin B Hemoperfusion in Abdominal Septic Shock (EUPHAS) [32], a single-center RCT in Italy, investigated the role of PMX-HP in severe sepsis/septic shock post abdominal surgery and showed that mortality at 28 days was significantly lower in the PMX-HP group than in the standard treatment group. This evidence concerns the gene HP and septic shock.