EZH2 and multiple sclerosis: In an attempt to characterize more in depth the cytosolic role of EZH2, Gunawan et al. [2] recently reported that EZH2 was critical for regulating leukocyte migration to sites of inflammation in EAE mice, findings that opened a potential and attractive link between EZH2 and autoimmune disorders such as multiple sclerosis in which cell adhesion and migration are critical pathogenic mechanisms [15].