Further, we showed growth impediment and induction of apoptosis in colorectal cancer cells induced by polyphenolic compound TAX, Down-regulation of Wnt/ β-catenin signal transduction pathway, Anti-proliferative effect of treatment of TAX, β-catenin Inhibitor (FH535) in HCT116 and HT29 cells, Flow cytometric analysis of colorectal cancer cells after TAX treatment for apoptosis and cell cycle, Inhibition of colony formation in HCT and HT29 cells after treatment with TAX and Alteration in CTNNB1 protein level after TAX treatment. This evidence concerns the gene CTNNB1 and colorectal cancer.