The estimated mean RFS time was shortened as follows: RFS for pN+ (vs. pN0) carcinomas was 6.7 (8.4) years, for pT3-pT4 -sized tumours (vs. pT1-pT2) 4.2 (7.9) years, and for low (vs. high) total HER3 expressing carcinomas 6.3 (8.0) years. This evidence concerns the gene ERBB3 and carcinoma.