Interestingly, we found that low HER3 expression was associated with features that commonly define breast cancer aggressiveness: large size (≥pT3), axillary lymph nodal infiltration (pN+), negative ER status, triple-negativity (ER-, PR-, HER2-) and basal phenotype (CK5/14+, ER-). The gene discussed is ERBB3; the disease is breast cancer.