HMOX1 and cancer: It is indeed plausible that the combination of DHA and Sorafenib could weaken the cellular antioxidant forces (targeting Bach1/Nrf2-mediated HO-1 gene expression) on the one hand and potentially enhance the oxidative potential (inhibiting soluble epoxide hydrolase to elevate DHA-derived epoxydocosapentaenoic acids) on the other hand, thereby leading to synergistic cytotoxicity against cancer cells.