TP53 and early-onset autosomal dominant Alzheimer disease: Enriched GO terms and KEGG pathways of DE genes include ribosome, metabolic pathways, p53 signaling pathway, MAPK signaling pathway and other disease-related pathways of Parkinson’s disease, Alzheimer’s disease, prostate cancer and bladder cancer, etc. (Additional file 5: Figure S2 and Additional file 6).