Pioglitazone and rosiglitazone have been shown to reduce in vitro activation of hepatic stellate cells, the cells responsible for extracellular matrix (ECM) deposition during hepatic fibrosis.11, 12 Despite pre-clinical data demonstrating a negative correlation between PPARγ expression level and tumorigenesis, few studies have evaluated the direct effects of TZDs on the fibrosis/cirrhosis/carcinogenesis axis in the liver. The gene discussed is PPARG; the disease is Cirrhosis.