Serum adiponectin levels are known to decrease in patients with cirrhosis and HCC as compared to healthy controls.19 We similarly observed decreased serum adiponectin levels in DEN-injured rats as compared to healthy PBS animals (37.3 ± 7 vs 62.9 ± 1.1; p < 0.05). The gene discussed is ADIPOQ; the disease is hepatocellular carcinoma.