We found that constitutive Rela overexpression significantly attenuated ENL’s inhibitory effects on viability and survival in the E0771 cell line, a model of basal-like breast cancer that is considered functionally triple-negative [21, 26, 46, 47], indicating that decreased activation of the p65 subunit of NF-κB is a key mediator of ENL’s effects in these cells. This evidence concerns the gene NFKB1 and breast cancer.