IL7R and lymphopenia: However, in accordance with the non-redundant role of IL-7 for T-cell homeostasis and the severe immunodeficient phenotype observed in IL-7 or IL-7Rα knock-out mice40,41, the efficacy of anti-IL-7Rα mAbs in rodents is generally associated with the induction of lymphopenia impacting both naive and memory T and B lymphocytes.