In line with data reported for other cancer types [16, 17], and with those provided by a publicly available microarray database, our findings reveal that ATGL transcript is remarkably reduced in human HCC, as well as in the diet-induced murine HCC model of steatohepatitis, in which immunohistochemical staining revealed a dramatic decrement of ATGL levels within cancerous lesions. Here, PNPLA2 is linked to hepatocellular carcinoma.