As shown in Fig. 3b, SMS, PDE8B, ERG, NAT1 and CAMKK2 are representative genes identified for each of these five categories, which were clearly evident in a clustering analyses of the 131 direct AR target genes that are differentially expressed based on ETS status in PCa, as well as by the relevant subtypes that have been identified for ETS+ and ETS− prostate tumors (Fig. 3c). Here, PDE8B is linked to posterior cortical atrophy.