To do so, we queried the 220 genes overexpressed in ETS+ cases and 193 genes overexpressed in ETS− cases in three publicly available AR ChIP-seq datasets [14], which defined direct AR targets as those genes that display AR binding to an androgen response element within 25 kb of the target gene’s promoter, in several PCa cell lines [12, 14, 15], primary prostate tumor tissues [15], and metastatic PCa [16]. Here, AR is linked to posterior cortical atrophy.