However, the results shown that NOX4 overexpression had little effect on the mROS production, glycolytic rate and deceased cell proliferation in p22phox null cells during hypoxia (Supplementary Fig. S5), directly showing to us that NOX4 regulates proliferation of papillary thyroid carcinoma cells through a way dependent on p22phox-NOX4 heterodimer complex. The gene discussed is NOX4; the disease is thyroid gland papillary carcinoma.